Alvesco

Clinical efficacy

Clinical studies have demonstrated that Alvesco® is at least as effective as other inhaled corticosteroids (ICSs).1–3 

Alvesco® has a fast onset of action and significantly decreases airway hyperresponsiveness after 2.5 hours of administration.4 It also has a prolonged duration of action, which allows for once-daily dosing. Desisobutyryl-ciclesonide (des-CIC) forms lipid conjugates in the lung,5 which, combined with the drug’s high lipophilicity, improves drug retention in the lung tissue.

Read on to find out how the clinical efficacy of Alvesco® compares with:

In this section, you can also find out how Alvesco® reduces inflammation in the small airways and improves small airway function.6–8

References
  1. Dahl R, Engelstatter R, Trebas-Pietras E, et al. A 24-week comparison of low-dose ciclesonide and fluticasone propionate in mild to moderate asthma. Respir Med 2010;104:1121-30.
  2. Ukena D, Biberger C, Steinijans V, et al. Ciclesonide is more effective than budesonide in the treatment of persistent asthma. Pulm Pharmacol Ther 2007;20:562-70.
  3. Boulet LP, Bateman ED, Voves R, et al. A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respir Med 2007;101:1677-86.
  4. Erin EM, Zacharasiewicz AS, Nicholson GC, et al. Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study. Chest 2008;134:740-5.
  5. Nave R, Meyer W, Fuhst R, et al. Formation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonide. Pulm Pharmacol Ther 2005;18:390-6.
  6. Hoshino M. Comparison of effectiveness in ciclesonide and fluticasone propionate on small airway function in mild asthma. Allergol Int 2010;59:59-66.
  7. Cohen J, Douma WR, ten Hacken NH, et al. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008;31:1213-20.
  8. Cohen J, Postma DS, Douma WR, et al. Particle size matters: diagnostics and treatment of small airways involvement in asthma. Eur Respir J 2011;37:532-40.
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